{"id":182594,"date":"2026-06-19T07:52:20","date_gmt":"2026-06-19T13:22:20","guid":{"rendered":"https:\/\/newslink360.space\/?p=182594"},"modified":"2026-06-19T07:52:20","modified_gmt":"2026-06-19T13:22:20","slug":"hypopigmented-mycosis-fungoides-shows-low-risk","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=182594","title":{"rendered":"Hypopigmented Mycosis Fungoides Shows Low Risk"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p>    A LARGE multicentre cohort study has found that hypopigmented <a href=\"https:\/\/www.emjreviews.com\/dermatology\/news\/jak2-gene-fusions-found-widely-across-cutaneous-t-cell-lymphomas\/\" target=\"_blank\" rel=\"noopener\">mycosis fungoides<\/a> (HMF) in adults generally follows an indolent clinical course, with most patients presenting with early-stage disease and responding well to skin-directed therapies.<\/p>\n<h2><strong>Insights from a Multicentre Hypopigmented Mycosis Fungoides Study<\/strong><\/h2>\n<p>The retrospective study analysed 224 adults with biopsy-confirmed HMF treated across six US tertiary referral centres between 2011 and 2023. The median age at diagnosis was 44 years, and most patients were Black (83%) and female (73%). Nearly all patients (98%) presented with early-stage disease.<\/p>\n<p>HMF is an uncommon variant of mycosis fungoides characterised by hypopigmented skin lesions, but data on its clinical behaviour in adults have been limited. In this cohort, 71% of patients presented with hypopigmented lesions alone, while 29% had mixed-variant disease. Outcomes did not differ significantly between these groups.<\/p>\n<p>Among 141 patients with available immunophenotyping data, CD8-positive predominance was observed in 63%. However, neither immunophenotype nor mixed-variant presentation appeared to influence disease progression or overall outcomes.<\/p>\n<p>Of the 207 patients who received treatment, 90% were managed with skin-directed therapies alone. Response data were available for 198 patients, showing a complete response in 26%, partial response in 51%, stable disease in 17%, and progressive disease in 6%.<\/p>\n<p>After a median follow-up of 39 months, stage progression occurred in only 14 patients (6%). Importantly, progression from early-stage to advanced-stage disease was rare, affecting just five of 219 patients (2%) who initially presented with early-stage HMF.<\/p>\n<p>The investigators also evaluated T-cell receptor (TCR) gene rearrangements. Peripheral blood TCR monoclonality was detected in 27% of tested patients and was associated with poorer treatment response. However, it was not linked to an increased risk of disease progression.<\/p>\n<h2><strong>Favourable Outcomes in Adult Hypopigmented Mycosis Fungoides<\/strong><\/h2>\n<p>Overall, the findings suggest that adult HMF has a favourable prognosis, with low rates of stage progression and good responses to skin-directed treatment. The authors found no independent baseline clinical or pathological factors associated with disease progression, highlighting the generally benign course of this rare mycosis fungoides subtype in adults.<\/p>\n<p><strong>Reference<\/strong><\/p>\n<p>Park JB et al. Clinicopathologic Features and Long-Term Outcomes of Adult Hypopigmented Mycosis Fungoides. JAMA Dermatol. 2026; DOI: 10.1001\/jamadermatol.2026.1793.<\/p>\n<p><em>Featured image: \u00a0Julia on Adobe Stock<\/em><\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.emjreviews.com\/dermatology\/news\/adult-hypopigmented-mycosis-fungoides-linked-to-low-progression-risk\/\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A LARGE multicentre cohort study has found that hypopigmented mycosis fungoides (HMF) in adults generally follows an indolent clinical course, with most patients presenting with early-stage disease and responding well&hellip;<\/p>\n","protected":false},"author":1,"featured_media":182595,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-182594","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/06\/2pm-derm-5.jpg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":174807,"url":"https:\/\/newslink360.space\/?p=174807","url_meta":{"origin":182594,"position":0},"title":"New genomic test may help millions of breast cancer patients avoid chemotherapy &#8211; CNBC TV18","author":"Ajay Kumar Verma","date":"May 30, 2026","format":false,"excerpt":"New genomic test may help millions of breast cancer patients avoid chemotherapy\u00a0\u00a0CNBC TV18Millions of breast cancer patients could safely avoid chemotherapy, study suggests\u00a0\u00a0BBCGroundbreaking genomic test could spare millions of breast cancer patients chemotherapy\u00a0\u00a0The GuardianSkip the chemo: Millions of breast cancer patients could be spared chemotherapy with groundbreaking genomic test\u00a0\u00a0The Times\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/05\/J6_coFbogxhRI9iM864NL_liGXvsQp2AupsKei7z0cNNfDvGUmWUy20nuUhkREQyrpY4bEeIBucs0-w300-rw.webp?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":181714,"url":"https:\/\/newslink360.space\/?p=181714","url_meta":{"origin":182594,"position":1},"title":"4D Motion Analysis Uncovers New Predictors for Heart Disease","author":"Ajay Kumar Verma","date":"June 17, 2026","format":false,"excerpt":"FOUR-DIMENSIONAL (4D) motion analysis of the left ventricle has unveiled six new motion phenogroups for determining cardiovascular disease outcomes and genetic risk, according to researchers from Imperial College London, United Kingdom. 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