{"id":186463,"date":"2026-06-27T06:53:22","date_gmt":"2026-06-27T12:23:22","guid":{"rendered":"https:\/\/newslink360.space\/?p=186463"},"modified":"2026-06-27T06:53:22","modified_gmt":"2026-06-27T12:23:22","slug":"prostate-volume-impacts-fusion-biopsy-cancer-detection","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=186463","title":{"rendered":"Prostate Volume Impacts Fusion Biopsy Cancer Detection"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p>    <span data-contrast=\"auto\">INCREASING prostate volume is associated with significantly lower prostate cancer detection rates using MRI\u2013ultrasound (MRI\u2013US) fusion-guided\u00a0<\/span><a href=\"https:\/\/www.emjreviews.com\/oncology\/news\/prostate-biopsy-route-may-influence-detection\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">biopsy<\/span><\/a><span data-contrast=\"auto\">,\u00a0according to a new study,\u00a0highlighting the need to consider gland size when planning diagnostic strategies.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">MRI\u2013US fusion biopsy has become\u00a0an important tool\u00a0in prostate cancer diagnosis, combining multiparametric MRI findings with targeted ultrasound-guided sampling. However, enlarged prostate glands may present diagnostic challenges due to reduced specificity of prostate-specific antigen (PSA), anatomical changes within the transition zone, and potential difficulties achieving\u00a0accurate\u00a0tissue sampling.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Researchers investigated whether prostate volume influences cancer detection outcomes following fusion biopsy, analysing data from 1,203 patients who underwent MRI\u2013US fusion-guided biopsy between 2014 and 2023. Patients were grouped according to prostate size, ranging from less than 30 mL to 120 mL or greater, and detection rates for overall prostate cancer and clinically significant prostate cancer (csPCa) were assessed.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Prostate Volume Affects MRI\u2013Ultrasound Biopsy Accuracy<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Overall, prostate cancer was detected in 62.0% of patients, with 39.5% diagnosed with clinically significant disease. However, detection rates declined progressively as prostate volume increased.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Patients with prostates smaller than 30 mL had the highest overall cancer detection rate at 82.3%. This fell to 67.1% in prostates measuring 30\u201354.9 mL, 50.2% in 55\u201379.9 mL, 48.5% in 80\u2013119.9 mL, and just 28.9% in prostates measuring 120 mL or more.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">A similar pattern was\u00a0observed\u00a0for clinically significant prostate cancer detection, which decreased from 59.4% in the smallest prostate group to 24.4% among patients with the largest glands.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Cancer Detection Declines Across PI-RADS Categories<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Further analysis showed that prostate volume\u00a0remained\u00a0an independent predictor of cancer detection after adjustment for other factors. Detection rates decreased with increasing gland size across all PI-RADS categories, suggesting that larger prostates may reduce the sensitivity of MRI-guided diagnostic approaches.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Among patients with PI-RADS 5 lesions, cancer detection decreased from 87.1% in prostates below 50 mL to 69.2% in prostates above 100\u00a0mL.\u00a0Similar reductions were\u00a0observed\u00a0for PI-RADS 4 and PI-RADS 3 lesions.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The study also found that larger prostates were associated with a greater proportion of anterior lesions and fewer positive digital rectal examinations, potentially contributing to diagnostic difficulty.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Findings Highlight Need for Tailored Biopsy Strategies<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">The authors concluded that prostate volume should be incorporated into clinical decision-making when assessing patients undergoing MRI\u2013US fusion biopsy. Larger glands may require adapted sampling approaches to improve cancer detection and reduce the risk of missed clinically significant disease.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">These findings emphasise the importance of personalised diagnostic pathways for men with enlarged prostates and suspected prostate cancer.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Reference<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Franz T et al<\/span><b><span data-contrast=\"auto\">.\u00a0<\/span><\/b><span data-contrast=\"auto\">Are big prostates a challenge? Correlation between prostate volume and detection rate in fusion biopsy of the prostate.\u00a0Adv Urol.\u00a02026;DOI:\u00a010.1155\/aiu\/5999882.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><i><span data-contrast=\"auto\">Featured image:\u00a0RFBSIP\u00a0on Adobe Stock<\/span><\/i><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.emjreviews.com\/urology\/news\/larger-prostates-reduce-cancer-detection-in-fusion-biopsy\/\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>INCREASING prostate volume is associated with significantly lower prostate cancer detection rates using MRI\u2013ultrasound (MRI\u2013US) fusion-guided\u00a0biopsy,\u00a0according to a new study,\u00a0highlighting the need to consider gland size when planning diagnostic strategies.\u00a0&hellip;<\/p>\n","protected":false},"author":1,"featured_media":186464,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-186463","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/06\/1pm-urol-2.jpg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":174807,"url":"https:\/\/newslink360.space\/?p=174807","url_meta":{"origin":186463,"position":0},"title":"New genomic test may help millions of breast cancer patients avoid chemotherapy &#8211; CNBC TV18","author":"Ajay Kumar Verma","date":"May 30, 2026","format":false,"excerpt":"New genomic test may help millions of breast cancer patients avoid chemotherapy\u00a0\u00a0CNBC TV18Millions of breast cancer patients could safely avoid chemotherapy, study suggests\u00a0\u00a0BBCGroundbreaking genomic test could spare millions of breast cancer patients chemotherapy\u00a0\u00a0The GuardianSkip the chemo: Millions of breast cancer patients could be spared chemotherapy with groundbreaking genomic test\u00a0\u00a0The Times\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/05\/J6_coFbogxhRI9iM864NL_liGXvsQp2AupsKei7z0cNNfDvGUmWUy20nuUhkREQyrpY4bEeIBucs0-w300-rw.webp?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":174575,"url":"https:\/\/newslink360.space\/?p=174575","url_meta":{"origin":186463,"position":1},"title":"Poop Tests And Blood Tests Join Colonoscopy As Options For Colorectal Cancer Screening &#8211; NDTV","author":"Ajay Kumar Verma","date":"May 30, 2026","format":false,"excerpt":"Poop Tests And Blood Tests Join Colonoscopy As Options For Colorectal Cancer Screening\u00a0\u00a0NDTVColorectal cancer: New guidelines add 2 types of screening tools\u00a0\u00a0Medical News TodayACS Updates CRC Guidelines to Include Guardant's Shield Blood Test\u00a0\u00a0Medical Device and Diagnostic industryBlood test added to colorectal cancer screening options by cancer group\u00a0\u00a0NBC NewsCentral IL surgeon\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/05\/J6_coFbogxhRI9iM864NL_liGXvsQp2AupsKei7z0cNNfDvGUmWUy20nuUhkREQyrpY4bEeIBucs0-w300-rw.webp?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":185408,"url":"https:\/\/newslink360.space\/?p=185408","url_meta":{"origin":186463,"position":2},"title":"Radiation Therapy May Carry Sexual Health Risks \u2013 EMJ","author":"Ajay Kumar Verma","date":"June 25, 2026","format":false,"excerpt":"RADIATION THERAPY for gynecologic cancers carries lasting adverse effects on sexual health, a new systematic review has found.1 Patient-Reported Outcomes Researchers analysed a total of 26 studies, comprising data from 5,646 patients. 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Insights from a Multicentre Hypopigmented Mycosis Fungoides Study The retrospective study analysed 224 adults with biopsy-confirmed HMF\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/2pm-derm-5.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/2pm-derm-5.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/2pm-derm-5.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/2pm-derm-5.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pgnRh4-Mvt","_links":{"self":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/186463","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=186463"}],"version-history":[{"count":0,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/186463\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/media\/186464"}],"wp:attachment":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=186463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=186463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=186463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}