{"id":187624,"date":"2026-06-29T17:05:15","date_gmt":"2026-06-29T22:35:15","guid":{"rendered":"https:\/\/newslink360.space\/?p=187624"},"modified":"2026-06-29T17:05:15","modified_gmt":"2026-06-29T22:35:15","slug":"alzheimer-disease-blood-biomarkers-after-tbi","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=187624","title":{"rendered":"Alzheimer Disease Blood Biomarkers After TBI"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p>    ALZHEIMER disease blood biomarkers may be less accurate in veterans with prior traumatic brain injury.<\/p>\n<h2>Alzheimer Disease Blood Biomarkers Show Reduced Accuracy<\/h2>\n<p>A history of <a href=\"https:\/\/www.emjreviews.com\/en-us\/amj\/neurology\/news\/whats-the-link-between-traumatic-brain-injury-and-alzheimers\/\" target=\"_blank\" rel=\"noopener\">traumatic brain injury (TBI)<\/a> may reduce the diagnostic accuracy of emerging Alzheimer disease blood biomarkers, according to new findings from a cross-sectional diagnostic test study of older veterans without dementia.<\/p>\n<p>The study evaluated whether plasma phosphorylated tau 217 (p-tau217)\/amyloid-\u03b2 42 (A\u03b242), an Alzheimer disease blood biomarker ratio used to detect amyloid positivity, performed equally well in individuals with and without prior TBI. Researchers analyzed existing data and banked plasma from 272 Vietnam War veterans enrolled between 2013 and 2020, all of whom were cognitively unimpaired or had mild cognitive impairment and had amyloid PET imaging available.<\/p>\n<p>Plasma biomarker analysis took place from 2024 to 2025, with data analysis completed between July 2025 and February 2026. Participants were grouped by TBI history, including no TBI, TBI with loss of consciousness for 0 to 5 minutes, and TBI with loss of consciousness for more than 5 minutes.<\/p>\n<h2>TBI Severity May Modify Test Performance<\/h2>\n<p>Among the 272 participants, mean age was 70 years, 99.3% were male, and 30.5% were amyloid PET positive. The plasma p-tau217\/A\u03b242 ratio showed high accuracy in veterans without TBI, reaching 90%. However, accuracy declined to 78% in those with TBI and loss of consciousness for 0 to 5 minutes, and to 63% in those with loss of consciousness for more than 5 minutes.<\/p>\n<p>The reduced performance appeared to be driven mainly by lower sensitivity, meaning the test may miss amyloid PET positive cases in individuals with TBI history. Similar patterns were observed for plasma p-tau217 alone and the plasma A\u03b242\/40 ratio.<\/p>\n<h2>Caution Needed When Interpreting Results<\/h2>\n<p>The findings suggest that TBI history and severity may modify the accuracy of Alzheimer disease blood biomarkers when predicting brain amyloid PET positivity. Results remained similar after excluding veterans with TBI within the previous 10 years and when amyloid PET positivity was defined using a quantitative threshold rather than consensus visual read.<\/p>\n<p>Clinically, the study raises concern that the p-tau217\/A\u03b242 ratio may miss more than half of amyloid PET positive cases among cognitively unimpaired individuals or those with mild cognitive impairment who have a TBI history. The authors advised caution when interpreting Alzheimer disease blood biomarkers in this setting, particularly as blood based testing becomes increasingly important in diagnostic pathways.<\/p>\n<p><strong>Reference<\/strong><br \/>Rosen-Lang Y et al. Prior traumatic brain injury and Alzheimer disease blood biomarkers. JAMA Neurol. 2026;10.1001\/jamaneurol.2026.2042.<\/p>\n<p>Featured Image: DC Studio on Adobe Stock.<\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.emjreviews.com\/neurology\/news\/tbi-history-may-complicate-alzheimer-blood-tests\/\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ALZHEIMER disease blood biomarkers may be less accurate in veterans with prior traumatic brain injury. Alzheimer Disease Blood Biomarkers Show Reduced Accuracy A history of traumatic brain injury (TBI) may&hellip;<\/p>\n","protected":false},"author":1,"featured_media":187625,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-187624","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_913247615.jpeg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":182594,"url":"https:\/\/newslink360.space\/?p=182594","url_meta":{"origin":187624,"position":0},"title":"Hypopigmented Mycosis Fungoides Shows Low Risk","author":"Ajay Kumar Verma","date":"June 19, 2026","format":false,"excerpt":"A LARGE multicentre cohort study has found that hypopigmented mycosis fungoides (HMF) in adults generally follows an indolent clinical course, with most patients presenting with early-stage disease and responding well to skin-directed therapies. Insights from a Multicentre Hypopigmented Mycosis Fungoides Study The retrospective study analysed 224 adults with biopsy-confirmed HMF\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/2pm-derm-5.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/2pm-derm-5.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/2pm-derm-5.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/2pm-derm-5.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":186485,"url":"https:\/\/newslink360.space\/?p=186485","url_meta":{"origin":187624,"position":1},"title":"Genetic marker linked to severe IBD outcomes","author":"Ajay Kumar Verma","date":"June 27, 2026","format":false,"excerpt":"HLA-DRB1*01:03\u00a0is associated with increased severity across\u00a0inflammatory bowel disease\u00a0(IBD)\u00a0phenotypes, including Crohn\u2019s disease and ulcerative colitis, according to a UK genotype\u2013phenotype study of 43,762 patients. Carriage of the allele was\u00a0identified\u00a0in 2,009 patients (4.6%) and showed consistent links with more aggressive disease behaviour.\u00a0 HLA-DRB1*01:03\u00a0and Severe IBD Outcomes\u00a0 In Crohn\u2019s disease,\u00a0HLA-DRB1*01:03\u00a0was associated with higher\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Gastro-2pm-3.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Gastro-2pm-3.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Gastro-2pm-3.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Gastro-2pm-3.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":182682,"url":"https:\/\/newslink360.space\/?p=182682","url_meta":{"origin":187624,"position":2},"title":"Ebola disease caused by Bundibugyo virus, Democratic Republic of the Congo &#038; Uganda","author":"Ajay Kumar Verma","date":"June 19, 2026","format":false,"excerpt":"\r \r \r \r \r \r Situation at a glance\r \r The Bundibugyo virus disease (BVD) outbreak in the Democratic Republic of the Congo continues to evolve rapidly, with sustained transmission and increasing numbers of reported cases. As of 17 June, a cumulative of 896 confirmed cases, including 232 deaths,\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/geographic-distribution-of-confirmed-cases-in-drc-and-uganda.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/geographic-distribution-of-confirmed-cases-in-drc-and-uganda.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/geographic-distribution-of-confirmed-cases-in-drc-and-uganda.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/geographic-distribution-of-confirmed-cases-in-drc-and-uganda.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":187396,"url":"https:\/\/newslink360.space\/?p=187396","url_meta":{"origin":187624,"position":3},"title":"Low grip strength should not be used as an independent predictor of prostate cancer in older men","author":"Ajay Kumar Verma","date":"June 29, 2026","format":false,"excerpt":"The unadjusted risk of prostate cancer is shown for old people aged: 50\u201364 years (A); 65\u201379 years (B); 80+ years (C); All ages (D). Credit: Maturitas (2026). DOI: https:\/\/doi.org\/10.1016\/j.maturitas.2026.108926 Low handgrip strength is a valuable indicator of overall health; it is not a reliable standalone predictor of increased prostate cancer\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/prostate-cancer-risk-by-hgs-lev.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/prostate-cancer-risk-by-hgs-lev.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/prostate-cancer-risk-by-hgs-lev.jpeg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/prostate-cancer-risk-by-hgs-lev.jpeg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/prostate-cancer-risk-by-hgs-lev.jpeg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":186463,"url":"https:\/\/newslink360.space\/?p=186463","url_meta":{"origin":187624,"position":4},"title":"Prostate Volume Impacts Fusion Biopsy Cancer Detection","author":"Ajay Kumar Verma","date":"June 27, 2026","format":false,"excerpt":"INCREASING prostate volume is associated with significantly lower prostate cancer detection rates using MRI\u2013ultrasound (MRI\u2013US) fusion-guided\u00a0biopsy,\u00a0according to a new study,\u00a0highlighting the need to consider gland size when planning diagnostic strategies.\u00a0 MRI\u2013US fusion biopsy has become\u00a0an important tool\u00a0in prostate cancer diagnosis, combining multiparametric MRI findings with targeted ultrasound-guided sampling. However, enlarged\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1pm-urol-2.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1pm-urol-2.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1pm-urol-2.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1pm-urol-2.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":187644,"url":"https:\/\/newslink360.space\/?p=187644","url_meta":{"origin":187624,"position":5},"title":"Rheumatoid Arthritis and Daily Participation","author":"Ajay Kumar Verma","date":"June 29, 2026","format":false,"excerpt":"RHEUMATOID arthritis may sharply reduce daily participation after onset, especially in leisure, household, and social roles. Rheumatoid Arthritis and Occupational Repertoire Rheumatoid arthritis (RA) may reshape everyday life well beyond joint symptoms, according to an observational study of Brazilian adults that found broad reductions in occupational repertoire after disease onset.\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_635051699.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_635051699.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_635051699.jpeg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_635051699.jpeg?resize=700%2C400&ssl=1 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pgnRh4-MOc","_links":{"self":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/187624","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=187624"}],"version-history":[{"count":0,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/187624\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/media\/187625"}],"wp:attachment":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=187624"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=187624"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=187624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}