{"id":187804,"date":"2026-06-30T02:15:29","date_gmt":"2026-06-30T07:45:29","guid":{"rendered":"https:\/\/newslink360.space\/?p=187804"},"modified":"2026-06-30T02:15:29","modified_gmt":"2026-06-30T07:45:29","slug":"paroxetine-targets-neurovascular-immune-pathways-in-rosacea","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=187804","title":{"rendered":"Paroxetine Targets Neurovascular-Immune Pathways in Rosacea"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p>    NEW research has explored how paroxetine may improve symptoms of refractory erythematous <a href=\"https:\/\/www.emjreviews.com\/dermatology\/news\/rosacea-linked-to-higher-risk-of-depression\/\" target=\"_blank\" rel=\"noopener\">rosacea<\/a> by altering systemic molecular pathways. The secondary analysis of a randomised clinical trial investigated changes in plasma proteins after treatment and identified potential biomarkers that could help predict which patients may respond.<\/p>\n<p>The study included 24 women with refractory rosacea who received oral paroxetine 25 mg daily for 12 weeks. Participants had persistent facial erythema despite previous treatments, with clinical outcomes assessed using the Clinician\u2019s Erythema Assessment (CEA) and Flushing Assessment Tool.<\/p>\n<p>After 12 weeks, paroxetine treatment was associated with significant improvements in both erythema and flushing symptoms. Mean CEA scores decreased from 3.1 to 2.3, while flushing scores fell from 3.1 to 2.0.<\/p>\n<h2><strong>Paroxetine Linked to Immune, Vascular and Neurological Pathway Changes<\/strong><\/h2>\n<p>Using plasma proteomic profiling with data-independent acquisition liquid chromatography-tandem mass spectrometry, researchers identified 497 proteins that changed following treatment.<\/p>\n<p>The altered proteins were mainly associated with pathways involved in immune activation, insulin receptor signalling, neuronal regulation and vascular function. Researchers also identified a subgroup of 98 \u201creversed-response\u201d proteins, which showed patterns suggesting a shift towards normalisation after treatment.<\/p>\n<p>These proteins were particularly linked to synaptic vesicle cycling and vascular smooth muscle contraction, supporting the theory that rosacea symptoms may involve interactions between nervous system regulation, inflammation and blood vessel responses.<\/p>\n<h2><strong>Candidate Biomarkers May Support Personalised Rosacea Treatment<\/strong><\/h2>\n<p>The study also examined whether protein changes could predict clinical improvement. Protein signatures were associated with reductions in erythema and flushing severity, with 65 proteins linked to erythema improvement and 73 linked to flushing improvement.<\/p>\n<p>Two proteins, OLFML3 and IGFBP2, showed potential as predictive biomarkers. OLFML3 demonstrated an area under the receiver operating characteristic curve (AUC) of 0.87, while IGFBP2 showed an AUC of 0.80, suggesting they may help identify patients more likely to benefit from paroxetine therapy.<\/p>\n<h2><strong>Future Directions for Rosacea Management<\/strong><\/h2>\n<p>The authors concluded that paroxetine may act beyond symptom control by influencing systemic neurovascular and immune pathways involved in rosacea. However, they emphasised that the findings are exploratory and require validation in larger patient populations.<\/p>\n<p>The results provide early evidence that circulating protein signatures could eventually support more personalised approaches to rosacea treatment, helping clinicians identify patients most likely to respond to specific therapies.<\/p>\n<p><strong>Reference<\/strong><\/p>\n<p>Wang B et al. Biomarkers of paroxetine response in refractory rosacea: a secondary analysis of a randomized clinical trial. JAMA Dermatol.2026;DOI: 10.1001\/jamadermatol.2026.1437.<\/p>\n<p><em>Featured image: Shauerman on Adobe Stock<\/em><\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.emjreviews.com\/dermatology\/news\/paroxetine-targets-neurovascular-immune-pathways-in-rosacea\/\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>NEW research has explored how paroxetine may improve symptoms of refractory erythematous rosacea by altering systemic molecular pathways. The secondary analysis of a randomised clinical trial investigated changes in plasma&hellip;<\/p>\n","protected":false},"author":1,"featured_media":187805,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-187804","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/06\/12pm-derm-1-940x587.jpg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":182079,"url":"https:\/\/newslink360.space\/?p=182079","url_meta":{"origin":187804,"position":0},"title":"Occupational Solar UV Exposure and Melanoma","author":"Ajay Kumar Verma","date":"June 18, 2026","format":false,"excerpt":"OCCUPATIONAL solar UV exposure was linked to higher melanoma risk in a nationwide Danish worker cohort. A large register-based study of Danish workers has found an exposure-response association between occupational solar UV exposure and cutaneous melanoma, strengthening concern that prolonged outdoor work may contribute to melanoma risk. The nationwide cohort\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_289823739.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_289823739.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_289823739.jpeg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_289823739.jpeg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":182145,"url":"https:\/\/newslink360.space\/?p=182145","url_meta":{"origin":187804,"position":1},"title":"Anxiety Symptoms and Grazing in Diabetes","author":"Ajay Kumar Verma","date":"June 18, 2026","format":false,"excerpt":"ANXIETY symptoms were positively associated with grazing behaviour and higher glycated haemoglobin levels among adults with type 2 diabetes, according to a recent cross-sectional study conducted in a public hospital setting. The findings suggest that psychological distress may contribute to maladaptive eating patterns that could affect glycaemic management. Anxiety Symptoms\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Diab-4pm.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Diab-4pm.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Diab-4pm.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Diab-4pm.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":185452,"url":"https:\/\/newslink360.space\/?p=185452","url_meta":{"origin":187804,"position":2},"title":"GI Severity and Renal Involvement in IgA Vasculitis","author":"Ajay Kumar Verma","date":"June 25, 2026","format":false,"excerpt":"SEVERE gastrointestinal involvement in paediatric IgA vasculitis is associated with renal involvement in children, according to a retrospective single centre cohort study examining clinical characteristics, gastrointestinal manifestations and renal outcomes between August 2023 and June 2024. Paediatric IgA Vasculitis and Renal Involvement IgA vasculitis is characterised by IgA dominant immune\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/11am-Neph.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/11am-Neph.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/11am-Neph.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/11am-Neph.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":185518,"url":"https:\/\/newslink360.space\/?p=185518","url_meta":{"origin":187804,"position":3},"title":"Hidradenitis Suppurativa and ICIs &#8211; AMJ","author":"Ajay Kumar Verma","date":"June 25, 2026","format":false,"excerpt":"HIDRADENITIS suppurativa may newly develop or flare in some patients receiving immune checkpoint inhibitor therapy. Hidradenitis Suppurativa During Cancer Immunotherapy Immune checkpoint inhibitors have transformed cancer treatment, but their immune-mediated effects can extend beyond tumor control. A new scoping review suggests that hidradenitis suppurativa may emerge after immune checkpoint inhibitor\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_837966512.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_837966512.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_837966512.jpeg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/AdobeStock_837966512.jpeg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":181714,"url":"https:\/\/newslink360.space\/?p=181714","url_meta":{"origin":187804,"position":4},"title":"4D Motion Analysis Uncovers New Predictors for Heart Disease","author":"Ajay Kumar Verma","date":"June 17, 2026","format":false,"excerpt":"FOUR-DIMENSIONAL (4D) motion analysis of the left ventricle has unveiled six new motion phenogroups for determining cardiovascular disease outcomes and genetic risk, according to researchers from Imperial College London, United Kingdom. Conventional cardiac assessment relies heavily on global volumetric measurements, which often fail to capture more subtle or early abnormalities\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":181154,"url":"https:\/\/newslink360.space\/?p=181154","url_meta":{"origin":187804,"position":5},"title":"Burden and Mechanism of Chronic Cough in People Living with Idiopathic Pulmonary Fibrosis","author":"Ajay Kumar Verma","date":"June 16, 2026","format":false,"excerpt":"Support: The publication of this article was funded by Trevi Therapeutics. Interviewees: Tejaswini Kulkarni,1 Matthew Drake,2 Steve Ashton3 1. The University of Alabama at Birmingham, USA2. Oregon Health and Science University, Portland, USA3. Person living with IPF, Ohio, USA Disclosure: Kulkarni has received consultation\/advisory\u202fboard fees from Avalyn Pharma, Brainomix, Boehringer\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/KOL-article-Resp-Burden-and-Mechanism-of-Chronic-Cough-in-People-Living-with-Idiopathic-Pulmonary-Fi.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/KOL-article-Resp-Burden-and-Mechanism-of-Chronic-Cough-in-People-Living-with-Idiopathic-Pulmonary-Fi.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/KOL-article-Resp-Burden-and-Mechanism-of-Chronic-Cough-in-People-Living-with-Idiopathic-Pulmonary-Fi.jpeg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/KOL-article-Resp-Burden-and-Mechanism-of-Chronic-Cough-in-People-Living-with-Idiopathic-Pulmonary-Fi.jpeg?resize=700%2C400&ssl=1 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pgnRh4-MR6","_links":{"self":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/187804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=187804"}],"version-history":[{"count":0,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/187804\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/media\/187805"}],"wp:attachment":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=187804"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=187804"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=187804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}