{"id":187869,"date":"2026-06-30T05:19:02","date_gmt":"2026-06-30T10:49:02","guid":{"rendered":"https:\/\/newslink360.space\/?p=187869"},"modified":"2026-06-30T05:19:02","modified_gmt":"2026-06-30T10:49:02","slug":"new-mechanism-for-gene-therapy-brain-delivery","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=187869","title":{"rendered":"New Mechanism for Gene Therapy Brain Delivery"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p>    <span data-contrast=\"auto\">MAJOR\u00a0steps forward in addressing drug delivery gap for neurological disorders in research published using\u00a0antibody-based\u00a0Brainshuttle\u2122\u00a0technology. Promising therapeutic\u00a0modalities\u00a0such as\u00a0RNA-based\u00a0antisense oligonucleotides (ASOs) can precisely regulate disease-related\u00a0genes but\u00a0face limited clinical utility as\u00a0they\u2019re\u00a0unable to cross the\u00a0<\/span><a href=\"https:\/\/www.emjreviews.com\/neurology\/news\/persistent-blood-brain-barrier-disruption-linked-to-cognitive-decline\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">blood brain barrier<\/span><\/a><span data-contrast=\"auto\">\u00a0(BBB).<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">TfR1 Engineering Reveals How ASO Cargo Influences Brain Delivery<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Previously,\u00a0transferrin receptor\u202f(tFR1) mediated shuttling has shown encouraging results, but the molecular mechanisms are\u00a0largely unknown. In this study, researchers optimised tFR1 binding by attaching ASOs to engineered delivery systems (antibody shuttles) to investigate their interaction with endothelial cells with the aim to overcome\u00a0<\/span><a href=\"https:\/\/www.emjreviews.com\/oncology\/news\/nanomedicine-breakthrough-improves-drug-delivery-in-pediatric-brain-tumors\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">systemic delivery<\/span><\/a><span data-contrast=\"auto\">\u00a0challenges.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Findings showed that ASO attachment improved binding and uptake for some lower-affinity<\/span><span data-contrast=\"none\">\u00a0<\/span><span data-contrast=\"auto\">tFR1-targeting shuttles, but reduced receptor engagement for higher affinity shuttles. This highlights that\u00a0ASO\u00a0structure and\u00a0payload can alter how the antibody binds, enters, and moves through BBB cells.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Dual-Targeting Approach Enhances BBB Transport<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Researchers also investigated CD98hc, an alternative BBB receptor as a potential delivery target. It was found that CD98hc followed a different cellular transport\u00a0pathway, and\u00a0showed a more favourable response to ASO conjugation. This target helped to avoid degradation pathways and peripheral clearance, positioning CD98hc as a potential alternative for future CNS therapies.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">In this study, researchers created a\u00a0bispecific\u00a0antibody designed to target both TfR1 and CD98hc simultaneously.\u00a0The dual targeting system combined the efficient uptake properties of TfR1 with the prolonged cellular residence associated with CD98hc, supporting stronger transport across BBB models.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Engineered Delivery Platforms Support Future CNS Therapies\u00a0<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">The delivered ASOs successfully reduced target RNA levels in neuron models,\u00a0demonstrating\u00a0functional activity after transport. Researchers highlight that the findings provide design principles for developing improved\u00a0CNS delivery platforms. Better BBB-crossing technologies could support future treatments for neurological disorders, including neurodegenerative diseases. Further studies are needed to confirm whether the approach translates into improved delivery and efficacy in animal models and clinical settings.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Reference\u00a0<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Sela T et al.\u00a0Impact\u00a0of ASO conjugation and receptor binding affinity on intracellular transport of mono- and bispecific\u00a0TfR- and CD98-Brainshuttle\u2122 variants.\u00a0mAbs.\u00a02026;DOI:10.1080\/19420862.2026.2691351.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><i><span data-contrast=\"auto\">Featured Image:\u00a0sinhyu\u00a0on Adobe Stock\u00a0<\/span><\/i><\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.emjreviews.com\/innovations\/news\/engineered-antibody-technology-boosts-brain-drug-delivery\/\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>MAJOR\u00a0steps forward in addressing drug delivery gap for neurological disorders in research published using\u00a0antibody-based\u00a0Brainshuttle\u2122\u00a0technology. Promising therapeutic\u00a0modalities\u00a0such as\u00a0RNA-based\u00a0antisense oligonucleotides (ASOs) can precisely regulate disease-related\u00a0genes but\u00a0face limited clinical utility as\u00a0they\u2019re\u00a0unable to cross&hellip;<\/p>\n","protected":false},"author":1,"featured_media":187870,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-187869","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/06\/10am-Innov-5.jpg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":185042,"url":"https:\/\/newslink360.space\/?p=185042","url_meta":{"origin":187869,"position":0},"title":"Amazon CEO Andy Jassy in India","author":"Ajay Kumar Verma","date":"June 24, 2026","format":false,"excerpt":"Jassy visits Amazon Now micro-fulfilment centre as company plans expanding the ultra-fast delivery service to 300 Indian cities Andy Jassy visited an Amazon Now micro-fulfilment centre that powers the company\u2019s ultra-fast delivery promise, with plans afoot to extend the service to more than 300 Indian cities. 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