{"id":189383,"date":"2026-07-03T08:49:10","date_gmt":"2026-07-03T14:19:10","guid":{"rendered":"https:\/\/newslink360.space\/?p=189383"},"modified":"2026-07-03T08:49:10","modified_gmt":"2026-07-03T14:19:10","slug":"study-describes-how-psychological-stress-can-alter-gut-microbiome-increase-risk-of-disease","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=189383","title":{"rendered":"Study describes how psychological stress can alter gut microbiome, increase risk of disease"},"content":{"rendered":"


\n<\/p>\n

\n
\"The<\/picture><\/div>\n

\n The findings provide a conceptual framework for developing new approaches to mitigate immune aging and stress-associated immune dysfunction |Image used for representational purpose only
\n | Photo Credit: Getty Images\/iStockphoto\n <\/p>\n<\/div>\n

\n
A study describes a mechanism in mice through which psychological stress can alter gut microbiome and thereby can increase risk of health conditions including heart disease and diabetes.<\/p>\n

Findings published in the journal Cell Stem Cell<\/i> psychological stress speeds up aging-like changes in the body’s blood-forming stem cells in the bone marrow — called hematopoietic stem cells — by altering the intestinal microbiota.<\/p>\n

“Our research shows how stress-responsive brain regions regulate the balance of the intestinal microbiota, which ultimately affects the function of hematopoietic stem cells,” senior author Meng Zhao of Sun Yat-sen University\u202fin Guangzhou, China, said.<\/p>\n

They added previous studies have shown that chronic stress can influence immune function and immune cell formation in the bone marrow through inflammatory pathways and adrenergic receptors, which drive the body’s ‘fight-or-flight’ response.<\/p>\n

However, how the stress signals were transmitted from the brain to the bone marrow was unclear, the team said.<\/p>\n

Four varied mouse models of stress were analysed to study interactions among the brain, intestine, and bone marrow.<\/p>\n

Chronic stress was found to reduce activity in two brain regions — the medial prefrontal cortex, which integrates emotional and cognitive information, and the periaqueductal gray, important for pain modulation.<\/p>\n

The reduced brain activity in turn induced a number of changes in the physiology of the mice, including loss of hematopoietic stem cells and reduced lymphocyte production, the researchers found.<\/p>\n

They also observed changes in signals sent to the intestines.<\/p>\n

For example, the stressed mice had a loss of Lactobacillus reuteri — a species important for maintaining a healthy balance of gut microbes — and lowered levels of spermidine, a naturally occurring compound crucial for clearing out damaged cells.<\/p>\n

“One surprising finding of our study was that suppression of only two specific brain regions was sufficient to produce many of the hematopoietic defects caused by psychological stress,” author Linjia Jiang, also of Sun Yat-sen University, said.<\/p>\n

“Alternations in the gut microbiota and in the microbial metabolite spermidine played a crucial role in mediating communication between the brain and the bone marrow,” Jiang said.<\/p>\n

How psychological stress alters the neural circuits in different disease settings and whether similar mechanisms operate in humans are some of the questions that remain and the team plans to study.<\/p>\n

They may also look at whether interventions could be developed to improve bone marrow function in aging or during times of chronic stress.<\/p>\n

The findings provide a conceptual framework for developing new approaches to mitigate immune ageing and stress-associated immune dysfunction, Zhao said.<\/p>\n

“Our findings raise the possibility that managing psychological stress may not only improve mental well-being but also help preserve immune function and promote healthy aging,” Jiang said.<\/p>\n<\/div>\n

\n

Published – July 03, 2026 07:04 pm IST<\/span><\/p>\n<\/div>\n<\/div>\n


\n
Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The findings provide a conceptual framework for developing new approaches to mitigate immune aging and stress-associated immune dysfunction |Image used for representational purpose only | Photo Credit: Getty Images\/iStockphoto A study describes a mechanism in mice through which psychological stress can alter gut microbiome and thereby can increase risk of health conditions including heart disease … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":189384,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-189383","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/07\/CCI_UDHindu_KSL_UF94DBCLH_R1532191044_7_6225eb21-4e9f-4179-bf41-b3b0bd85a52b.jpg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":171371,"url":"https:\/\/newslink360.space\/?p=171371","url_meta":{"origin":189383,"position":0},"title":"New Study Links Daily Almond Consumption to Better Brain and Metabolic Health in Adults with Prediabetes – Deccan Chronicle","author":"Ajay Kumar Verma","date":"May 23, 2026","format":false,"excerpt":"New Study Links Daily Almond Consumption to Better Brain and Metabolic Health in Adults with Prediabetes\u00a0\u00a0Deccan ChronicleHealth Research Continues to Fuel Almond Growth\u00a0\u00a0Growing ProduceNew research shows how snacking on almonds improves diets\u00a0\u00a0MorningstarEating Almonds Daily Could Fix Your Gut, Metabolism And Appetite; Study Explains How\u00a0\u00a0NDTVAlmond Benefits: Just One Handful Of Badam\u2026","rel":"","context":"In "National News"","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/03\/J6_coFbogxhRI9iM864NL_liGXvsQp2AupsKei7z0cNNfDvGUmWUy20nuUhkREQyrpY4bEeIBucs0-w300-rw.webp?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":181714,"url":"https:\/\/newslink360.space\/?p=181714","url_meta":{"origin":189383,"position":1},"title":"4D Motion Analysis Uncovers New Predictors for Heart Disease","author":"Ajay Kumar Verma","date":"June 17, 2026","format":false,"excerpt":"FOUR-DIMENSIONAL (4D) motion analysis of the left ventricle has unveiled six new motion phenogroups for determining cardiovascular disease outcomes and genetic risk, according to researchers from Imperial College London, United Kingdom. Conventional cardiac assessment relies heavily on global volumetric measurements, which often fail to capture more subtle or early abnormalities\u2026","rel":"","context":"In "National News"","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":182013,"url":"https:\/\/newslink360.space\/?p=182013","url_meta":{"origin":189383,"position":2},"title":"Infertility Risk Linked to Delayed Parental Conception","author":"Ajay Kumar Verma","date":"June 18, 2026","format":false,"excerpt":"ADULTS born to parents who took longer to conceive may face a higher risk of infertility themselves, according to findings from a Danish cohort study investigating potential intergenerational patterns of reproductive health.1 The study also found that a maternal history of infertility was linked to a greater likelihood of infertility\u2026","rel":"","context":"In "National News"","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-Repro-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-Repro-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-Repro-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-Repro-1.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":186485,"url":"https:\/\/newslink360.space\/?p=186485","url_meta":{"origin":189383,"position":3},"title":"Genetic marker linked to severe IBD outcomes","author":"Ajay Kumar Verma","date":"June 27, 2026","format":false,"excerpt":"HLA-DRB1*01:03\u00a0is associated with increased severity across\u00a0inflammatory bowel disease\u00a0(IBD)\u00a0phenotypes, including Crohn\u2019s disease and ulcerative colitis, according to a UK genotype\u2013phenotype study of 43,762 patients. Carriage of the allele was\u00a0identified\u00a0in 2,009 patients (4.6%) and showed consistent links with more aggressive disease behaviour.\u00a0 HLA-DRB1*01:03\u00a0and Severe IBD Outcomes\u00a0 In Crohn\u2019s disease,\u00a0HLA-DRB1*01:03\u00a0was associated with higher\u2026","rel":"","context":"In "National News"","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Gastro-2pm-3.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Gastro-2pm-3.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Gastro-2pm-3.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Gastro-2pm-3.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":188833,"url":"https:\/\/newslink360.space\/?p=188833","url_meta":{"origin":189383,"position":4},"title":"Air Pollution and Haemodialysis Outcomes","author":"Ajay Kumar Verma","date":"July 2, 2026","format":false,"excerpt":"AIR POLLUTION may significantly influence hospital admission and mortality risk among patients receiving haemodialysis, according to a retrospective study examining environmental exposures in end stage kidney disease. Air Pollution Linked to Adverse Outcomes Environmental factors are increasingly recognised as important determinants of health, particularly in vulnerable populations. Researchers investigated the\u2026","rel":"","context":"In "National News"","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neph-11am-2.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neph-11am-2.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neph-11am-2.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neph-11am-2.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":186311,"url":"https:\/\/newslink360.space\/?p=186311","url_meta":{"origin":189383,"position":5},"title":"Heart Attack Prevention: How safe are statins really? New Oxford research finds the side effects of this cholesterol-lowering drug on muscles","author":"Ajay Kumar Verma","date":"June 26, 2026","format":false,"excerpt":"For years, Statins have been a staple in medicine cabinets, especially for people who are on a journey to lower their cholesterol levels and protect their hearts. If you have high cholesterol or a history of heart problems, chances are your healthcare provider has talked to you about them or\u2026","rel":"","context":"In "National News"","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1782537214_photo.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1782537214_photo.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1782537214_photo.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1782537214_photo.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1782537214_photo.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pgnRh4-Ngz","_links":{"self":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/189383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=189383"}],"version-history":[{"count":0,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/189383\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/media\/189384"}],"wp:attachment":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=189383"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=189383"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=189383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}