{"id":189403,"date":"2026-07-03T09:50:36","date_gmt":"2026-07-03T15:20:36","guid":{"rendered":"https:\/\/newslink360.space\/?p=189403"},"modified":"2026-07-03T09:50:36","modified_gmt":"2026-07-03T15:20:36","slug":"cholesterol-drives-dcm-heart-cell-dysfunction","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=189403","title":{"rendered":"Cholesterol Drives DCM Heart Cell Dysfunction"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p>    ABNORMAL cholesterol signalling identified as a key regulator of cardiomyocyte structure and function in new research using patient-derived heart tissue. Findings suggest lipid signalling may contribute directly to disease progression in dilated cardiomyopathy (DCM).<\/p>\n<p><a href=\"https:\/\/www.emjreviews.com\/cardiology\/news\/heart-failure-predicted-up-to-five-years-early\/\" target=\"_blank\" rel=\"noopener\">Heart failure<\/a> remains a major clinical challenge with limited disease-modifying options for many patients. While genetic and structural abnormalities are known contributors, the molecular mechanisms driving cardiomyocyte dysfunction remain incompletely understood.<\/p>\n<h2><strong>Cholesterol Dysregulation Linked to Cardiomyocyte Dysfunction <\/strong><\/h2>\n<p>Researchers investigated cardiomyocytes carrying DCM-associated mutations affecting sarcomere proteins. They mapped lipid changes associated with disease using human iPSC-derived cardiomyocytes, patient heart tissue, and adult cardiomyocytes.<\/p>\n<p>It was found that abnormal <a href=\"https:\/\/www.emjreviews.com\/cardiology\/news\/novel-cholesterol-drug-outperforms-existing-treatments\/\" target=\"_blank\" rel=\"noopener\">cholesterol <\/a>handling may actively drive cellular dysfunction with elevated intracellular levels identified in DCM cardiomyocytes. Cholesterol accumulation was linked to abnormal endoplasmic reticulum (ER) structure and impaired ER function.<\/p>\n<h2><strong>ER\u2013sarcomere Disruption Contributes to DCM Progression <\/strong><\/h2>\n<p>Findings also indicated a bidirectional relationship whereby sarcomere misalignment affected ER structure and lipid balance, in turn, lipid imbalance further worsened cellular architecture and contractility. The changes were linked to impaired cardiomyocyte contraction, reinforcing heart disease progression.<\/p>\n<p>Researchers identified disruption of ER\u2013sarcomere contact sites as a key mechanism connecting structural defects with altered lipid metabolism. Loss of these interactions appeared to impair cellular organisation and contribute to the progressive decline in cardiomyocyte function observed in DCM.<\/p>\n<h2><strong>Targeting Cholesterol Pathways Restores Cardiomyocyte Function <\/strong><\/h2>\n<p>Researchers found that correcting intracellular cholesterol levels helped restore ER membrane structure and sarcomere organisation. As well as this, cholesterol normalisation improved contractile function in DCM cardiomyocyte models. The study positions lipid-driven cellular dysfunction as a future strategy for disease -modifying heart failure treatment.<\/p>\n<p>The findings uncovered new mechanistic insights into ow lipid metabolism, ER structure, and sarcomere organisation interact in DCM and identifies a potential route toward therapies that address the underlying biology of cardiomyocyte failure. Future research will be needed to determine whether targeting this pathway can improve outcomes in patients with heart failure.<\/p>\n<p><strong>Reference <\/strong><\/p>\n<p>Ignatyeva N et al. Targeting intracellular cholesterol imbalance rescues sarcomere\u2013ER contact site signaling and ER remodeling in dilated cardiomyopathy. Signal Transduct Target Ther. 2026;11:237.<\/p>\n<p><em>Featured Image: JosLuis on Adobe Stock<\/em><\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.emjreviews.com\/cardiology\/news\/cholesterol-pathway-disruption-drives-dcm-cell-damage\/\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ABNORMAL cholesterol signalling identified as a key regulator of cardiomyocyte structure and function in new research using patient-derived heart tissue. Findings suggest lipid signalling may contribute directly to disease progression in dilated cardiomyopathy (DCM). Heart failure remains a major clinical challenge with limited disease-modifying options for many patients. While genetic and structural abnormalities are known &#8230; <a title=\"Cholesterol Drives DCM Heart Cell Dysfunction\" class=\"read-more\" href=\"https:\/\/newslink360.space\/?p=189403\" aria-label=\"Read more about Cholesterol Drives DCM Heart Cell Dysfunction\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":189404,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-189403","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/07\/4pm-Cardio-2.jpg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":186311,"url":"https:\/\/newslink360.space\/?p=186311","url_meta":{"origin":189403,"position":0},"title":"Heart Attack Prevention: How safe are statins really? 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If you have high cholesterol or a history of heart problems, chances are your healthcare provider has talked to you about them or\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1782537214_photo.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1782537214_photo.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1782537214_photo.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1782537214_photo.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/1782537214_photo.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":189383,"url":"https:\/\/newslink360.space\/?p=189383","url_meta":{"origin":189403,"position":1},"title":"Study describes how psychological stress can alter gut microbiome, increase risk of disease","author":"Ajay Kumar Verma","date":"July 3, 2026","format":false,"excerpt":"The findings provide a conceptual framework for developing new approaches to mitigate immune aging and stress-associated immune dysfunction |Image used for representational purpose only | Photo Credit: Getty Images\/iStockphoto A study describes a mechanism in mice through which psychological stress can alter gut microbiome and thereby can increase risk of\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/CCI_UDHindu_KSL_UF94DBCLH_R1532191044_7_6225eb21-4e9f-4179-bf41-b3b0bd85a52b.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/CCI_UDHindu_KSL_UF94DBCLH_R1532191044_7_6225eb21-4e9f-4179-bf41-b3b0bd85a52b.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/CCI_UDHindu_KSL_UF94DBCLH_R1532191044_7_6225eb21-4e9f-4179-bf41-b3b0bd85a52b.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/CCI_UDHindu_KSL_UF94DBCLH_R1532191044_7_6225eb21-4e9f-4179-bf41-b3b0bd85a52b.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/CCI_UDHindu_KSL_UF94DBCLH_R1532191044_7_6225eb21-4e9f-4179-bf41-b3b0bd85a52b.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":185408,"url":"https:\/\/newslink360.space\/?p=185408","url_meta":{"origin":189403,"position":2},"title":"Radiation Therapy May Carry Sexual Health Risks \u2013 EMJ","author":"Ajay Kumar Verma","date":"June 25, 2026","format":false,"excerpt":"RADIATION THERAPY for gynecologic cancers carries lasting adverse effects on sexual health, a new systematic review has found.1 Patient-Reported Outcomes Researchers analysed a total of 26 studies, comprising data from 5,646 patients. In analysis, 11 studies focused on cervical cancer, seven on endometrial cancer, and eight on mixed gynecological malignancies.\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-repro-2.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-repro-2.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-repro-2.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-repro-2.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":181714,"url":"https:\/\/newslink360.space\/?p=181714","url_meta":{"origin":189403,"position":3},"title":"4D Motion Analysis Uncovers New Predictors for Heart Disease","author":"Ajay Kumar Verma","date":"June 17, 2026","format":false,"excerpt":"FOUR-DIMENSIONAL (4D) motion analysis of the left ventricle has unveiled six new motion phenogroups for determining cardiovascular disease outcomes and genetic risk, according to researchers from Imperial College London, United Kingdom. Conventional cardiac assessment relies heavily on global volumetric measurements, which often fail to capture more subtle or early abnormalities\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":181132,"url":"https:\/\/newslink360.space\/?p=181132","url_meta":{"origin":189403,"position":4},"title":"Heart Failure: A Multisystem Cardiometabolic Disease","author":"Ajay Kumar Verma","date":"June 16, 2026","format":false,"excerpt":"Heart failure (HF) is a clinical syndrome in which structural or functional abnormalities impair cardiac filling or ejection.1 Global prevalence has more than doubled from 25.43 million in 1990 to >64 million people in 2023 and remains a leading cause of hospitalisation in adults aged >65 years. UK prevalence is\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Heart-Failure-A-Multisystem-Cardiometabolic-Disease-web.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Heart-Failure-A-Multisystem-Cardiometabolic-Disease-web.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Heart-Failure-A-Multisystem-Cardiometabolic-Disease-web.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Heart-Failure-A-Multisystem-Cardiometabolic-Disease-web.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":188833,"url":"https:\/\/newslink360.space\/?p=188833","url_meta":{"origin":189403,"position":5},"title":"Air Pollution and Haemodialysis Outcomes","author":"Ajay Kumar Verma","date":"July 2, 2026","format":false,"excerpt":"AIR POLLUTION may significantly influence hospital admission and mortality risk among patients receiving haemodialysis, according to a retrospective study examining environmental exposures in end stage kidney disease. Air Pollution Linked to Adverse Outcomes Environmental factors are increasingly recognised as important determinants of health, particularly in vulnerable populations. Researchers investigated the\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neph-11am-2.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neph-11am-2.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neph-11am-2.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neph-11am-2.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pgnRh4-NgT","_links":{"self":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/189403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=189403"}],"version-history":[{"count":0,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/189403\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/media\/189404"}],"wp:attachment":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=189403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=189403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=189403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}