{"id":190167,"date":"2026-07-05T06:45:00","date_gmt":"2026-07-05T12:15:00","guid":{"rendered":"https:\/\/newslink360.space\/?p=190167"},"modified":"2026-07-05T06:45:00","modified_gmt":"2026-07-05T12:15:00","slug":"gastric-cancer-risk-score-validated","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=190167","title":{"rendered":"Gastric Cancer Risk Score Validated"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p>    RESEARCHERS have developed and validated an oesophageal and <a href=\"https:\/\/www.emjreviews.com\/gastroenterology\/news\/novel-biomarkers-predict-survival-in-gastric-cancer\/\" target=\"_blank\" rel=\"noopener\">gastric cancer<\/a> risk score using UK Biobank data, designed to identify adults aged over 50 at elevated risk of upper gastrointestinal cancer using only self-reported clinical and lifestyle information.<\/p>\n<h2><strong>Gastric Cancer Risk Score<\/strong><\/h2>\n<p>Researchers drew on 375,280 participants aged 50 years and older within the UK Biobank cohort to derive a screening tool for gastric and oesophageal cancer risk.<\/p>\n<p>Candidate predictors included sociodemographic factors, lifestyle behaviours, medication use and medical history, with selection restricted to variables reliably self-reported in routine care contexts. Using COX regression models with LASSO penalisation, the final model retained eight predictors: sex, age, smoking status, alcohol consumption, body mass index, history of oesophagitis, use of gastric acid inhibitors, and prior surgery involving the stomach or oesophagus.<\/p>\n<h2><strong>Strengths and Limitations<\/strong><\/h2>\n<p>Authors noted several strengths and limitations of this study. The risk score is based on a large, well-characterised UK Biobank cohort with a median follow-up of 11.7 years, exceeding that of many comparable studies. It uses simple, self-reported variables that are widely available in the general population and straightforward to obtain, supporting ease of implementation.<\/p>\n<p>However, limitations remain. Relevant predictors may have been missed due to data constraints within UK Biobank. Although LASSO regression guided variable selection, alternative methods may have identified different predictors. Additional interactions between variables may also exist but were not fully explored. The model was developed in a single-country UK population, which may limit transferability to other settings without further evaluation.<\/p>\n<h2><strong>Conclusion<\/strong><\/h2>\n<p>To conclude, a self-reported risk score for oesophageal and gastric cancer has been developed for individuals aged over 50 years in a low-to-middle incidence setting. Based on eight simple variables, it showed moderate discriminatory performance and identified a small high-risk subgroup defined by a 10-year risk threshold of at least 1%. The authors note that further work within the RISC-GAP project will assess whether adding clinical and biomarker data can improve prediction. Any future implementation will depend on evidence of mortality benefit and cost-effectiveness of a risk-adapted screening approach.<\/p>\n<p><strong>Reference<\/strong><\/p>\n<p>Schmitz T et al. Risk score for esophageal and gastric cancer in the over 50-year-old population based on self-reported information -the RISC-GAP project. BMC Gastroenterol. 2026;26(1):387.<\/p>\n<p><em>Featured Image: Claytonon\/peopleimages.com on Adobe Stock<\/em><\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.emjreviews.com\/gastroenterology\/news\/gastric-cancer-risk-score-validated-in-uk-biobank\/\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>RESEARCHERS have developed and validated an oesophageal and gastric cancer risk score using UK Biobank data, designed to identify adults aged over 50 at elevated risk of upper gastrointestinal cancer using only self-reported clinical and lifestyle information. Gastric Cancer Risk Score Researchers drew on 375,280 participants aged 50 years and older within the UK Biobank &#8230; <a title=\"Gastric Cancer Risk Score Validated\" class=\"read-more\" href=\"https:\/\/newslink360.space\/?p=190167\" aria-label=\"Read more about Gastric Cancer Risk Score Validated\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":190168,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-190167","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-1pm.jpg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":187396,"url":"https:\/\/newslink360.space\/?p=187396","url_meta":{"origin":190167,"position":0},"title":"Low grip strength should not be used as an independent predictor of prostate cancer in older men","author":"Ajay Kumar Verma","date":"June 29, 2026","format":false,"excerpt":"The unadjusted risk of prostate cancer is shown for old people aged: 50\u201364 years (A); 65\u201379 years (B); 80+ years (C); All ages (D). Credit: Maturitas (2026). DOI: https:\/\/doi.org\/10.1016\/j.maturitas.2026.108926 Low handgrip strength is a valuable indicator of overall health; it is not a reliable standalone predictor of increased prostate cancer\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/prostate-cancer-risk-by-hgs-lev.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/prostate-cancer-risk-by-hgs-lev.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/prostate-cancer-risk-by-hgs-lev.jpeg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/prostate-cancer-risk-by-hgs-lev.jpeg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/prostate-cancer-risk-by-hgs-lev.jpeg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":181714,"url":"https:\/\/newslink360.space\/?p=181714","url_meta":{"origin":190167,"position":1},"title":"4D Motion Analysis Uncovers New Predictors for Heart Disease","author":"Ajay Kumar Verma","date":"June 17, 2026","format":false,"excerpt":"FOUR-DIMENSIONAL (4D) motion analysis of the left ventricle has unveiled six new motion phenogroups for determining cardiovascular disease outcomes and genetic risk, according to researchers from Imperial College London, United Kingdom. Conventional cardiac assessment relies heavily on global volumetric measurements, which often fail to capture more subtle or early abnormalities\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/Cardio-4pm.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":190149,"url":"https:\/\/newslink360.space\/?p=190149","url_meta":{"origin":190167,"position":2},"title":"Changes in Lymph Node Network Impacts Breast Cancer \u2013 EMJ","author":"Ajay Kumar Verma","date":"July 5, 2026","format":false,"excerpt":"CHANGES in the structure of lymph nodes could one day help identify people who are at higher or lower risk of breast cancer spreading, new research has revealed. Structural Changes in Lymph Nodes Lymph nodes in the armpit are often the first place that breast cancer spreads to. Determining whether\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/12pm-onc.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/12pm-onc.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/12pm-onc.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/12pm-onc.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":185408,"url":"https:\/\/newslink360.space\/?p=185408","url_meta":{"origin":190167,"position":3},"title":"Radiation Therapy May Carry Sexual Health Risks \u2013 EMJ","author":"Ajay Kumar Verma","date":"June 25, 2026","format":false,"excerpt":"RADIATION THERAPY for gynecologic cancers carries lasting adverse effects on sexual health, a new systematic review has found.1 Patient-Reported Outcomes Researchers analysed a total of 26 studies, comprising data from 5,646 patients. In analysis, 11 studies focused on cervical cancer, seven on endometrial cancer, and eight on mixed gynecological malignancies.\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-repro-2.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-repro-2.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-repro-2.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/06\/9am-repro-2.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":189811,"url":"https:\/\/newslink360.space\/?p=189811","url_meta":{"origin":190167,"position":4},"title":"Study links obesity to 19 cancers: Why excess fat is more than \u2018cosmetic concern\u2019 | Health News","author":"Ajay Kumar Verma","date":"July 4, 2026","format":false,"excerpt":"A large new review of more than 1.5 million cancer cases has found that obesity is linked to a higher risk of 19 different types of cancer, reinforcing its role as a major, preventable risk factor. A study published in Nature Metabolism identified new associations with cancers such as leukaemia,\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/BMI.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/BMI.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/BMI.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/BMI.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/BMI.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/BMI.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":188437,"url":"https:\/\/newslink360.space\/?p=188437","url_meta":{"origin":190167,"position":5},"title":"Predicting Pain in Early Rheumatoid Arthritis","author":"Ajay Kumar Verma","date":"July 1, 2026","format":false,"excerpt":"A THIRD of patients still suffer unacceptable pain two years after a rheumatoid arthritis diagnosis, usually with little inflammation to explain it, a 10,000-patient Swedish study finds, pointing to predictors clinicians could spot at diagnosis. Pain in Early Rheumatoid Arthritis Pain that lingers despite controlled inflammation remains a major burden\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/3pm-rheum-5.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/3pm-rheum-5.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/3pm-rheum-5.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/3pm-rheum-5.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pgnRh4-Ntd","_links":{"self":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/190167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=190167"}],"version-history":[{"count":0,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/190167\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/media\/190168"}],"wp:attachment":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=190167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=190167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=190167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}