{"id":193130,"date":"2026-07-13T17:20:45","date_gmt":"2026-07-13T22:50:45","guid":{"rendered":"https:\/\/newslink360.space\/?p=193130"},"modified":"2026-07-13T17:20:45","modified_gmt":"2026-07-13T22:50:45","slug":"prison-leprosy-screening-detects-hidden-cases","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=193130","title":{"rendered":"Prison Leprosy Screening Detects Hidden Cases"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p>    LEPROSY screening identified undiagnosed multibacillary disease and disability among incarcerated men in northeastern Brazil.<\/p>\n<h2>Leprosy Screening Reveals Missed Cases<\/h2>\n<p>Researchers conducted an observational cross sectional study at a high security male penitentiary in Macei\u00f3, Alagoas, where 915 people were incarcerated in a facility designed for 773. The team distributed the 14 item Leprosy Suspicion Questionnaire as an <a href=\"https:\/\/www.emjreviews.com\/en-us\/amj\/microbiology-infectious-diseases\/abstract\/incidence-of-mycobacterium-tuberculosis-screening-and-detection-in-people-living-with-hiv-in-custody-within-the-illinois-department-of-corrections-j100125\/\" target=\"_blank\" rel=\"noopener\">active case finding tool<\/a>, receiving 842 completed questionnaires. Of these, 240, or 28.5%, indicated signs or symptoms consistent with possible leprosy.<\/p>\n<p>Neurodermatological examinations were completed in 260 participants with both positive and negative questionnaire results. Eight new cases were diagnosed, producing an overall new case detection rate of 3.08%. Among the 92 examined participants with positive questionnaire results, six had leprosy, raising the detection rate to 6.52%.<\/p>\n<p>The questionnaire was positive in 75% of diagnosed cases, compared with 34.1% of participants without leprosy. Numbness in the hands and feet and nerve pain were the most frequently reported symptoms among diagnosed participants.<\/p>\n<h2>Neurological Disease Present at Diagnosis<\/h2>\n<p>All eight cases were classified as multibacillary leprosy and showed peripheral nerve involvement. Six participants had borderline forms and two had pure neural leprosy. Approximately 62.5% experienced dysesthesia without classical skin lesions, highlighting the potential for neurological manifestations to complicate recognition.<\/p>\n<p>Every diagnosed participant had physical disability at detection. Seven had Grade 1 disability and one had Grade 2 disability, indicating that disease had progressed before diagnosis. All newly diagnosed individuals were referred for standard multidrug therapy.<\/p>\n<h2>Serology Highlights Potential Screening Marker<\/h2>\n<p>Serological testing was performed on plasma from 244 clinically evaluated participants. Among the eight diagnosed cases, anti-Mce1A IgA antibodies were detected in 100%, while IgM and IgG antibodies were positive in 37.5% and 25%, respectively. Anti-PGL-I serology was negative in all diagnosed cases.<\/p>\n<p>Among participants without a clinical diagnosis, anti-Mce1A IgM seropositivity reached 37.7%, compared with 19.9% for anti-PGL-I. The researchers noted that these results may reflect exposure or subclinical infection, but the small number of diagnosed cases prevented reliable assessment of diagnostic accuracy.<\/p>\n<p>The findings support structured leprosy screening and follow-up in incarcerated populations. However, only 260 of 842 questionnaire respondents received clinical examinations because the study was suspended following a potential riot, meaning the detected cases may represent only part of the true burden.<\/p>\n<p><strong>Reference<\/strong><br \/>de Lucena TS et al. Hidden burden of leprosy in incarcerated populations in northeast Brazil: active case detection and serological assessment. Eur J Clin Microbiol Infect Dis. 2026; doi:10.1007\/s10096-026-05578-2.<\/p>\n<p>Featured Image: M+Isolation+Photo on Adobe Stock.<\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.emjreviews.com\/dermatology\/news\/prison-screening-exposes-hidden-burden-of-leprosy\/\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>LEPROSY screening identified undiagnosed multibacillary disease and disability among incarcerated men in northeastern Brazil. Leprosy Screening Reveals Missed Cases Researchers conducted an observational cross sectional study at a high security male penitentiary in Macei\u00f3, Alagoas, where 915 people were incarcerated in a facility designed for 773. The team distributed the 14 item Leprosy Suspicion Questionnaire&#8230;<\/p>\n","protected":false},"author":1,"featured_media":193131,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-193130","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/07\/AdobeStock_699964653.jpeg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":198480,"url":"https:\/\/newslink360.space\/?p=198480","url_meta":{"origin":193130,"position":0},"title":"ICNMD 2026 Interview: Wolfgang Grisold","author":"Ajay Kumar Verma","date":"July 29, 2026","format":false,"excerpt":"Wolfgang Grisold | Former President, World Federation of Neurology (WFN); Steering Committee and Programme Committee, International Congress of Neuromuscular Disease (ICNMD) Citation: EMJ Neurol. 2026; https:\/\/doi.org\/10.33590\/emjneurol\/7097860A As a member of both the International Congress of Neuromuscular Disease (ICNMD) Steering Committee and Programme Committee, you helped shape this year\u2019s Congress. 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