{"id":194395,"date":"2026-07-18T03:53:59","date_gmt":"2026-07-18T09:23:59","guid":{"rendered":"https:\/\/newslink360.space\/?p=194395"},"modified":"2026-07-18T03:53:59","modified_gmt":"2026-07-18T09:23:59","slug":"sds-toothpaste-affects-oesophageal-barrier-function","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=194395","title":{"rendered":"SDS Toothpaste Affects Oesophageal Barrier Function"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p>    <span data-contrast=\"auto\">Brushing with toothpaste\u00a0containing\u00a0the detergent sodium dodecyl\u00a0sulfate\u00a0(SDS) may temporarily impair oesophageal barrier function and alter salivary properties in healthy adults, according to a small human study. The findings provide new evidence supporting the hypothesis that environmental detergent exposure could contribute to mechanisms implicated in\u00a0<\/span><a href=\"https:\/\/www.emjreviews.com\/gastroenterology\/news\/study-identifies-genetic-markers-in-eosinophilic-oesophagitis\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">eosinophilic oesophagitis<\/span><\/a><span data-contrast=\"auto\">\u00a0(EoE).<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">EoE is characterised by epithelial barrier dysfunction, and\u00a0previous\u00a0experimental studies have shown that SDS can disrupt the oesophageal epithelium and promote eosinophilic inflammation in animal models. However, its effects in humans have\u00a0remained\u00a0unclear.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">SDS\u00a0Toothpaste Reduces Mucosal Impedance<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Researchers recruited 12 healthy adults, 10 of whom completed the study. Participants brushed their teeth with 2 g of an SDS-containing toothpaste before undergoing continuous oesophageal mucosal impedance monitoring, a marker of epithelial barrier integrity. Saliva samples were collected to measure SDS concentrations, while oesophageal string tests and proteomic analyses were performed before and after toothbrushing.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">SDS was detected\u00a0immediately\u00a0after brushing in all participants\u2019\u00a0initial\u00a0expectorate, with concentrations varying considerably. Notably, the detergent remained detectable in saliva in 80% of participants one hour after brushing.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Within 30 minutes of toothbrushing, oesophageal mucosal impedance had fallen significantly (p&lt;0.01), suggesting an acute reduction in epithelial barrier function.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">SDS\u00a0Toothpaste Alters Salivary\u00a0and Immune Responses<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">The investigators also\u00a0observed\u00a0changes in saliva and oesophageal protein expression following toothbrushing. Salivary viscosity increased, alongside elevated levels of proteins involved in mucosal defence.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Proteomic analysis\u00a0identified\u00a0downregulation of the tight junction pathway, which plays a key role in\u00a0maintaining\u00a0epithelial barrier integrity. At the same time, pathways involved in salivary secretion and the complement and coagulation cascades were upregulated in the proximal oesophagus,\u00a0indicating\u00a0activation of local mucosal immune responses.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">SDS\u00a0Toothpaste Findings Warrant Further Investigation<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">The authors conclude that SDS-containing toothpaste can remain in saliva for prolonged periods at concentrations previously shown to disrupt oesophageal epithelial cells in laboratory studies. In healthy adults, this exposure was associated with transient reductions in oesophageal mucosal impedance, altered salivary characteristics, and activation of mucosal immune pathways.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Although the study was small and conducted in healthy volunteers rather than patients with EoE, the findings provide mechanistic evidence that common household detergents may influence oesophageal barrier function. Larger clinical studies are now needed to\u00a0determine\u00a0whether repeated exposure to SDS contributes to the development or progression of eosinophilic oesophagitis in susceptible individuals.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Reference<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Wright BL et al.\u00a0Detergent-Containing Toothpaste Decreases\u00a0Esophageal\u00a0Mucosal Impedance and Alters Salivary Properties in Humans. Allergy. 2026;\u00a010.1111\/all.70437.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><i><span data-contrast=\"auto\">Featured image:\u00a0HappyRichStudio\u00a0on Adobe Stock<\/span><\/i><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.emjreviews.com\/allergy-immunology\/news\/sds-toothpaste-affects-oesophageal-barrier-function\/\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Brushing with toothpaste\u00a0containing\u00a0the detergent sodium dodecyl\u00a0sulfate\u00a0(SDS) may temporarily impair oesophageal barrier function and alter salivary properties in healthy adults, according to a small human study. The findings provide new evidence supporting the hypothesis that environmental detergent exposure could contribute to mechanisms implicated in\u00a0eosinophilic oesophagitis\u00a0(EoE).\u00a0 EoE is characterised by epithelial barrier dysfunction, and\u00a0previous\u00a0experimental studies have shown&#8230;<\/p>\n","protected":false},"author":1,"featured_media":194396,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-194395","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/07\/10am-allergy-3.jpg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":194634,"url":"https:\/\/newslink360.space\/?p=194634","url_meta":{"origin":194395,"position":0},"title":"Managing Sleep Deprivation in Clinical Practice","author":"Ajay Kumar Verma","date":"July 19, 2026","format":false,"excerpt":"Physiological Impacts of Sleep Deprivation SUSTAINED sleep deprivation disrupts multiple organ systems, requiring targeted clinical interventions to prevent chronic diseases. 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