{"id":194439,"date":"2026-07-18T08:03:02","date_gmt":"2026-07-18T13:33:02","guid":{"rendered":"https:\/\/newslink360.space\/?p=194439"},"modified":"2026-07-18T08:03:02","modified_gmt":"2026-07-18T13:33:02","slug":"psc-uc-shares-mast-cell-state-with-uc","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=194439","title":{"rendered":"PSC-UC Shares Mast Cell State with UC"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p>    <a href=\"https:\/\/www.emjreviews.com\/hepatology\/article\/primary-sclerosing-cholangitis-a-clinical-update\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">PRIMARY\u00a0sclerosing cholangitis<\/span><\/a><span data-contrast=\"auto\">\u00a0(PSC) and ulcerative colitis (UC)\u00a0exhibit\u00a0distinct colonic mucosa\u00a0topography but share similar cell\u00a0programmes during active disease, providing insights that could help guide tailored clinical management, according to a new study.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">PSC-UC<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">PSC\u00a0is a chronic, progressing cholestatic disease that\u00a0frequently\u00a0co-occurs with inflammatory bowel disease\u00a0(PSC-IBD).<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">When PSC affects the colon, it is referred to as PSC-ulcerative colitis (PSC-UC). Although PSC-UC resembles conventional UC, it is characterised by less severe disease flares, right-sided colonic predominance, and a greater lifetime risk of colorectal cancer than UC alone.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The aim of this study was to\u00a0reveal the differences in the fundamental biology between PSC-UC and UC.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Distinct\u00a0Mucosa Topography\u00a0in\u00a0PSC-UC<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Researchers\u00a0combined\u00a0single-cell mRNA and antigen receptor sequencing, 16S ribosomal RNA gene analysis and spatial transcriptomics on biopsies from four colon regions of patients with PSC-UC and UC during endoscopic remission\u00a0or at the time of relapse.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Results\u00a0indicated\u00a0that\u00a0the PSC-UC colon\u00a0harboured\u00a0distinct\u00a0mucosal-adherent\u00a0microbial\u00a0communities\u00a0when compared\u00a0to\u00a0healthy controls\u00a0and the\u00a0UC colon. These mucosal-adherent\u00a0communities\u00a0were\u00a0also\u00a0region-specific.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Interestingly,\u00a0the researchers also\u00a0identified\u00a0an\u00a0enrichment\u00a0of activated\u202fCD8 T\u00a0cells\u00a0and\u00a0\u03b3\u03b4\u00a0T cells at the right colon,\u00a0even in\u00a0the\u00a0absence of\u00a0histological inflammation.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Mast Cell Population<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Contrastingly, a\u00a0potentially pro-tumourigenic\u202fTMEM176B<\/span><span data-contrast=\"auto\">+<\/span><span data-contrast=\"auto\">\u202fmast cell population\u00a0was\u00a0enriched in the colon during disease relapse in both PSC-UC and UC.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The findings suggest that despite fundamental biological differences between the two conditions, they share similar cell programmes during active disease, including this mast cell state.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Conclusion<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">The study\u00a0demonstrates\u00a0that PSC-UC and UC are biologically distinct diseases with distinct colonic mucosal topographies, despite sharing common immune cell programmes during active disease. According to the authors, these findings provide\u00a0insights that may help inform more tailored clinical management and the development of precision therapies for patients with PSC-UC.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Reference\u00a0<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Tearle\u00a0JL\u202fet al.\u202fPrimary sclerosing cholangitis displays distinct colonic mucosa topography yet a shared mast cell state with ulcerative colitis.\u202fNat Commun.\u202f2026;DOI:10.1038\/s41467-026-75231-1.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><i><span data-contrast=\"auto\">Featured Image:\u00a0fizkes\u00a0on Adobe Stock.<\/span><\/i><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.emjreviews.com\/gastroenterology\/news\/primary-sclerosing-cholangitis-and-uc-share-common-mast-cell-state\/\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PRIMARY\u00a0sclerosing cholangitis\u00a0(PSC) and ulcerative colitis (UC)\u00a0exhibit\u00a0distinct colonic mucosa\u00a0topography but share similar cell\u00a0programmes during active disease, providing insights that could help guide tailored clinical management, according to a new study.\u00a0 PSC-UC\u00a0 PSC\u00a0is a chronic, progressing cholestatic disease that\u00a0frequently\u00a0co-occurs with inflammatory bowel disease\u00a0(PSC-IBD).\u00a0 When PSC affects the colon, it is referred to as PSC-ulcerative colitis (PSC-UC). Although&#8230;<\/p>\n","protected":false},"author":1,"featured_media":194440,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-194439","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-2pm-2.jpg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":194676,"url":"https:\/\/newslink360.space\/?p=194676","url_meta":{"origin":194439,"position":0},"title":"Serum REG3\u03b1 for Ulcerative Colitis Monitoring","author":"Ajay Kumar Verma","date":"July 19, 2026","format":false,"excerpt":"SERUM REG3\u03b1 biomarker testing was associated with clinical and endoscopic disease activity in patients with ulcerative colitis, supporting its potential as a blood-based adjunct for disease monitoring. The findings also suggest improved performance when interpreted alongside C reactive protein (CRP), although further validation is needed. Serum REG3\u03b1 Biomarker Linked to\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-1pm-3.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-1pm-3.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-1pm-3.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-1pm-3.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":195984,"url":"https:\/\/newslink360.space\/?p=195984","url_meta":{"origin":194439,"position":1},"title":"3D Organoid Models in Motor Neuron Diseases","author":"Ajay Kumar Verma","date":"July 23, 2026","format":false,"excerpt":"NEW RESEARCH has revealed how human 3D organoid models can uncover the mechanisms driving motor neuron diseases, offering fresh insight into the cell-autonomous and non-cell-autonomous processes that lead to progressive motor neuron loss, paralysis, and death. Rethinking the Mechanisms of Motor Neuron Diseases Motor neuron diseases have traditionally been viewed\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/3pm-neuro-3.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/3pm-neuro-3.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/3pm-neuro-3.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/3pm-neuro-3.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":195164,"url":"https:\/\/newslink360.space\/?p=195164","url_meta":{"origin":194439,"position":2},"title":"Colitis Protection through Apiin Pathways \u2013 EMJ","author":"Ajay Kumar Verma","date":"July 21, 2026","format":false,"excerpt":"COLITIS\u00a0protection was associated with microbiota dependent\u00a0apiin\u00a0activity, with new findings showing that the dietary flavone glycoside was transformed into apigenin and linked to increased butyrate production. The research investigated how\u00a0apiin\u00a0influenced dextran\u00a0sulphate\u00a0sodium\u00a0(DSS)-induced colitis and\u00a0identified\u00a0gut microbial metabolism as a key factor in its protective effects.\u00a0 Apiin\u00a0Transformation Supports Colitis Protection\u00a0 Dietary glycosides are microbiota\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-12pm.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-12pm.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-12pm.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-12pm.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":195831,"url":"https:\/\/newslink360.space\/?p=195831","url_meta":{"origin":194439,"position":3},"title":"EHA 2026 Abstract Highlights &#8211; European Medical Journal","author":"Ajay Kumar Verma","date":"July 23, 2026","format":false,"excerpt":"These abstracts highlight some of the cutting-edge research presented at the European Hematology Association (EHA) 2026 Congress. Covering topics ranging from liquid biopsy and cardiovascular risk to pregnancy complications and rare inherited blood disorders, the findings showcase emerging advances that could influence future diagnosis, risk stratification, and patient management across\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Hema-14.1-Congress-Review-thumbnail.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Hema-14.1-Congress-Review-thumbnail.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Hema-14.1-Congress-Review-thumbnail.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Hema-14.1-Congress-Review-thumbnail.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":194092,"url":"https:\/\/newslink360.space\/?p=194092","url_meta":{"origin":194439,"position":4},"title":"Gangliosides for Neuroprotection and Neurorepair","author":"Ajay Kumar Verma","date":"July 17, 2026","format":false,"excerpt":"GANGLIOSIDES serve as vital sialylated glycosphingolipids within the central nervous system, where they maintain membrane stability and coordinate intercellular signaling. A recent review highlights their therapeutic prospects across several neurodegenerative disorders and acute traumatic injuries. Cellular Energetics and Metabolic Coupling Recent research shows that the monosialoganglioside GM1 directly reinforces astrocyte-neuron\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/AdobeStock_104436208.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/AdobeStock_104436208.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/AdobeStock_104436208.jpeg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/AdobeStock_104436208.jpeg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":194417,"url":"https:\/\/newslink360.space\/?p=194417","url_meta":{"origin":194439,"position":5},"title":"CKD and Cognitive Decline After Stroke \u2013 EMJ","author":"Ajay Kumar Verma","date":"July 18, 2026","format":false,"excerpt":"CHRONIC KIDNEY DISEASE\u00a0has been\u00a0associated with greater post-stroke cognitive decline, according to new evidence from\u00a0Seoul, Republic of\u00a0Korea.\u00a0 The findings come from a retrospective\u00a0population-based\u00a0study of 359,572 individuals who underwent repeated standardised cognitive assessments.\u00a0\u00a0 Researchers examined\u00a0data\u00a0from the Korean National Health Insurance Service and Long-Term Care Insurance databases.\u00a0Changes in cognitive function\u00a0were evaluated\u00a0using repeated cognitive\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neuro-12pm.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neuro-12pm.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neuro-12pm.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Neuro-12pm.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pgnRh4-OA7","_links":{"self":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/194439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=194439"}],"version-history":[{"count":0,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/194439\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/media\/194440"}],"wp:attachment":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=194439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=194439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=194439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}