{"id":195164,"date":"2026-07-21T05:48:19","date_gmt":"2026-07-21T11:18:19","guid":{"rendered":"https:\/\/newslink360.space\/?p=195164"},"modified":"2026-07-21T05:48:19","modified_gmt":"2026-07-21T11:18:19","slug":"colitis-protection-through-apiin-pathways-emj","status":"publish","type":"post","link":"https:\/\/newslink360.space\/?p=195164","title":{"rendered":"Colitis Protection through Apiin Pathways \u2013 EMJ"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p>    <a href=\"https:\/\/www.emjreviews.com\/gastroenterology\/congress-review\/whats-new-in-ulcerative-colitis-j050123\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">COLITIS<\/span><\/a><span data-contrast=\"auto\">\u00a0protection was associated with microbiota dependent\u00a0apiin\u00a0activity, with new findings showing that the dietary flavone glycoside was transformed into apigenin and linked to increased butyrate production. The research investigated how\u00a0apiin\u00a0influenced dextran\u00a0sulphate\u00a0sodium\u00a0(DSS)-induced colitis and\u00a0identified\u00a0gut microbial metabolism as a key factor in its protective effects.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Apiin\u00a0Transformation Supports Colitis Protection<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Dietary glycosides are microbiota responsive food components with potential intestinal health benefits, although their mechanisms\u00a0remain\u00a0unclear.\u00a0Apiin, a naturally occurring flavone glycoside found in\u00a0plant-based\u00a0foods,\u00a0demonstrated\u00a0protective effects against colitis after undergoing microbial biotransformation in the distal intestine. The compound resisted host digestion but was efficiently converted by intestinal microbiota through\u00a0deglycosylation, producing apigenin, the bioactive aglycone.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Following\u00a0apiin\u00a0administration, researchers\u00a0observed\u00a0reduced colitis severity, with improvements in clinical and histopathological outcomes. The findings also showed lower production of pro-inflammatory cytokines, including TNF-\u03b1, IL-1\u03b2, IL-6, alongside restoration of intestinal barrier integrity.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">These results suggested that\u00a0apiin\u00a0activity depended on interactions between dietary components and the gut microbiota, highlighting the importance of microbial metabolism in regulating intestinal inflammation.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Microbiota\u00a0and Butyrate Pathways Influence Colitis<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Multi-omics analyses revealed that\u00a0apiin\u00a0reshaped gut microbiota composition and function, resulting in enhanced production of butyrate, a short-chain fatty acid associated with intestinal regulation. This metabolic change was linked to pathways involving G-protein coupled receptors and\u00a0PPAR\u03b3, as well as modulation of\u00a0NF-\u03baB-driven\u00a0inflammatory responses.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The findings\u00a0indicated\u00a0that\u00a0apiin\u00a0may influence colitis through a combination of microbial transformation and downstream metabolic signalling. The relationship between\u00a0apiin, microbiota activity, and butyrate production\u00a0provided\u00a0further insight into how dietary glycosides may affect inflammatory processes within the intestine.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Microbiota Transfer Confirms\u00a0Apiin\u00a0Effects<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">The role of the microbiota in\u00a0apiin\u00a0mediated colitis protection was further supported by faecal microbiota transplantation experiments. These experiments reproduced the protective effects\u00a0observed\u00a0after\u00a0apiin\u00a0administration, confirming that microbial communities contributed to the compound\u2019s activity.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Conclusion<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Overall, the study\u00a0identified\u00a0apiin\u00a0as a microbiota-dependent pro-flavonoid with potential relevance for understanding mechanisms involved in colitis regulation. Its conversion into apigenin and association with butyrate related signalling pathways were linked to reduced inflammation and improved intestinal outcomes in experimental colitis.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Reference<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Guo Z\u00a0et al.\u00a0Microbiota-dependent biotransformation of\u00a0apiin\u00a0drives butyrate-associated protection against colitis.\u202fnpj\u00a0Sci Food.\u00a02026;DOI:10.1038\/s41538-026-00992-4<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><i><span data-contrast=\"auto\">Featured Image:\u00a0MithaArini\u00a0on Adobe Stock.<\/span><\/i><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.emjreviews.com\/gastroenterology\/news\/colitis-protection-linked-to-microbiota-driven-apiin-activity\/\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>COLITIS\u00a0protection was associated with microbiota dependent\u00a0apiin\u00a0activity, with new findings showing that the dietary flavone glycoside was transformed into apigenin and linked to increased butyrate production. The research investigated how\u00a0apiin\u00a0influenced dextran\u00a0sulphate\u00a0sodium\u00a0(DSS)-induced colitis and\u00a0identified\u00a0gut microbial metabolism as a key factor in its protective effects.\u00a0 Apiin\u00a0Transformation Supports Colitis Protection\u00a0 Dietary glycosides are microbiota responsive food components with potential&#8230;<\/p>\n","protected":false},"author":1,"featured_media":195165,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-195164","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-12pm.jpg","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":194676,"url":"https:\/\/newslink360.space\/?p=194676","url_meta":{"origin":195164,"position":0},"title":"Serum REG3\u03b1 for Ulcerative Colitis Monitoring","author":"Ajay Kumar Verma","date":"July 19, 2026","format":false,"excerpt":"SERUM REG3\u03b1 biomarker testing was associated with clinical and endoscopic disease activity in patients with ulcerative colitis, supporting its potential as a blood-based adjunct for disease monitoring. The findings also suggest improved performance when interpreted alongside C reactive protein (CRP), although further validation is needed. Serum REG3\u03b1 Biomarker Linked to\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-1pm-3.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-1pm-3.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-1pm-3.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-1pm-3.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":194439,"url":"https:\/\/newslink360.space\/?p=194439","url_meta":{"origin":195164,"position":1},"title":"PSC-UC Shares Mast Cell State with UC","author":"Ajay Kumar Verma","date":"July 18, 2026","format":false,"excerpt":"PRIMARY\u00a0sclerosing cholangitis\u00a0(PSC) and ulcerative colitis (UC)\u00a0exhibit\u00a0distinct colonic mucosa\u00a0topography but share similar cell\u00a0programmes during active disease, providing insights that could help guide tailored clinical management, according to a new study.\u00a0 PSC-UC\u00a0 PSC\u00a0is a chronic, progressing cholestatic disease that\u00a0frequently\u00a0co-occurs with inflammatory bowel disease\u00a0(PSC-IBD).\u00a0 When PSC affects the colon, it is referred to\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-2pm-2.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-2pm-2.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-2pm-2.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Gastro-2pm-2.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":194634,"url":"https:\/\/newslink360.space\/?p=194634","url_meta":{"origin":195164,"position":2},"title":"Managing Sleep Deprivation in Clinical Practice","author":"Ajay Kumar Verma","date":"July 19, 2026","format":false,"excerpt":"Physiological Impacts of Sleep Deprivation SUSTAINED sleep deprivation disrupts multiple organ systems, requiring targeted clinical interventions to prevent chronic diseases. Clinical evidence indicates that sleep deprivation triggers acute neuroinflammation by activating microglial pathways and elevating circulating levels of interleukin-6 and tumor necrosis factor-alpha. These inflammatory responses increase blood-brain barrier permeability\u2026","rel":"","context":"In &quot;National News&quot;","block_context":{"text":"National News","link":"https:\/\/newslink360.space\/?cat=7"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/AdobeStock_2033078174.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/AdobeStock_2033078174.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/AdobeStock_2033078174.jpeg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/AdobeStock_2033078174.jpeg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":194960,"url":"https:\/\/newslink360.space\/?p=194960","url_meta":{"origin":195164,"position":3},"title":"Like slim phones? Techno&#8217;s new phone has premium design and powerful specifications","author":"Ajay Kumar Verma","date":"July 20, 2026","format":false,"excerpt":"Techno has introduced a new smartphone in its Camon series. The company has launched Tecno Camon Slim in the global market, the biggest feature of which is its 6.39mm ultra-slim design. Despite being thin, the phone has a large battery, high refresh rate display and 50MP Sony camera. At present\u2026","rel":"","context":"In &quot;Top Stories&quot;","block_context":{"text":"Top Stories","link":"https:\/\/newslink360.space\/?cat=119"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Tecno-Camon-Slim-1-2026-06-198769a34a652a4a6b2062bfd89cda55-1200x675.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Tecno-Camon-Slim-1-2026-06-198769a34a652a4a6b2062bfd89cda55-1200x675.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Tecno-Camon-Slim-1-2026-06-198769a34a652a4a6b2062bfd89cda55-1200x675.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Tecno-Camon-Slim-1-2026-06-198769a34a652a4a6b2062bfd89cda55-1200x675.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Tecno-Camon-Slim-1-2026-06-198769a34a652a4a6b2062bfd89cda55-1200x675.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":197530,"url":"https:\/\/newslink360.space\/?p=197530","url_meta":{"origin":195164,"position":4},"title":"Nissan Tekton turned out to be powerful! Scored full 5-stars in crash test, safe for both children and adults","author":"Ajay Kumar Verma","date":"July 26, 2026","format":false,"excerpt":"Last Updated:July 10, 2026, 11:29 ISTNissan Tekton has made a big claim in the compact SUV segment by achieving 5-star safety rating in Bharat NCAP crash test. The SUV has received excellent scores in both adult and child occupant protection. With a starting price of \u20b9 10.49 lakh, powerful turbo-petrol\u2026","rel":"","context":"In &quot;Top Stories&quot;","block_context":{"text":"Top Stories","link":"https:\/\/newslink360.space\/?cat=119"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Nissan-Tekton-Crash-Test-2026-07-b242d96c260076ea4045493c10cb4259-1200x675.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Nissan-Tekton-Crash-Test-2026-07-b242d96c260076ea4045493c10cb4259-1200x675.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Nissan-Tekton-Crash-Test-2026-07-b242d96c260076ea4045493c10cb4259-1200x675.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Nissan-Tekton-Crash-Test-2026-07-b242d96c260076ea4045493c10cb4259-1200x675.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Nissan-Tekton-Crash-Test-2026-07-b242d96c260076ea4045493c10cb4259-1200x675.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":195476,"url":"https:\/\/newslink360.space\/?p=195476","url_meta":{"origin":195164,"position":5},"title":"Tecno Camon Slim will come with LED light effects and premium design, will it compete with Samsung, Vivo?","author":"Ajay Kumar Verma","date":"July 22, 2026","format":false,"excerpt":"Powered by :Last Updated:June 20, 2026, 09:35 ISTTecno Camon Slim can be launched on June 21. The phone is expected to have 6.39mm slim design, MediaTek Dimensity 7100 processor, 5600mAh battery and Sony LYTIA camera. Know all the details revealed before the launch.news quicklyTecno Camon Slim teaser released, may launch\u2026","rel":"","context":"In &quot;Top Stories&quot;","block_context":{"text":"Top Stories","link":"https:\/\/newslink360.space\/?cat=119"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Tecno-Camon-Slim-2026-06-b7bdae024ed9d2cfe03f306b533cb1e4-1200x675.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Tecno-Camon-Slim-2026-06-b7bdae024ed9d2cfe03f306b533cb1e4-1200x675.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Tecno-Camon-Slim-2026-06-b7bdae024ed9d2cfe03f306b533cb1e4-1200x675.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Tecno-Camon-Slim-2026-06-b7bdae024ed9d2cfe03f306b533cb1e4-1200x675.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/newslink360.space\/wp-content\/uploads\/2026\/07\/Tecno-Camon-Slim-2026-06-b7bdae024ed9d2cfe03f306b533cb1e4-1200x675.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pgnRh4-OLO","_links":{"self":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/195164","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=195164"}],"version-history":[{"count":0,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/posts\/195164\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=\/wp\/v2\/media\/195165"}],"wp:attachment":[{"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=195164"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=195164"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newslink360.space\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=195164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}